When taken separately, vitamins D3, K1, and K2 are essential micronutrients that provide necessary functions for sustainable health. However, taken together, vitamins D3, K1, and K2 work together to complement each other’s supposed benefits. Specifically, Vitamin D3 supports calcium absorption, while Vitamin K1 supports bone health and healthy blood clotting, while Vitamin K2 helps transport calcium to both bones and teeth. This vitamin combination therefore offers holistic benefits in a wide array of human bodily areas.

For general daily maintenance, a typical combined dose is: Vitamin D3: 1,000–2,000 IU per day and 90–200 mcg per day of Vitamin K2. However, your ideal amount can vary. The best way to know your proper Vitamin D3 dose is to test blood levels of 25(OH)D3 with a healthcare provider. If levels are low, higher short-term doses like 5,000 IU/day for about 4 weeks may be used under medical supervision.

Always talk to your doctor before using Vitamin D or K, especially since Vitamin K can interact with medications.

It depends! Whether or not one should take a D3, K1, and K2 combination supplement depends entirely upon the individual and their needs. Specifically, individuals should consider taking a D3, K1, and K2 supplement daily if they:

• Do not have adequate sun exposure and/or participate in consistent outdoor activities.
• Have little D3, K1, and K2 intake from diet. Specifically, fermented foods, egg yolks, green leafy vegetables, specific types of fruit, and fish are high in Vitamin D3, K1, and K2. If you are a vegetarian, vegan, or have other miscellaneous dietary restrictions, discuss taking a D3, K1, and K2 supplement with your primary care physician.
• Have low blood levels of Vitamin D
• Are 50+ in age and/or have concerns with your bone health

Taken responsibly and with the careful and deliberate consultation of a doctor, Vitamin D3, K1, and K2 can lead to many supposed benefits, including but not limited to:

• Improved bone density
• More balanced mood and hormone regulation
• Increased muscle strength
• Improved heart health
• Improved insulin sensitivity
• Improved brain health

While Vitamin D and Vitamin K are generally safe and complementary when taken together, there are some contraindications and caution. For most healthy adults, taking vitamins D and K together is safe and even beneficial, as vitamin D supports calcium absorption while vitamin K helps direct calcium into bones and away from arteries. However, caution is needed in people with certain conditions: vitamin D can worsen high calcium levels, kidney disease, kidney stones, or certain granulomatous diseases, while vitamin K can interfere with blood-thinning medications like warfarin and may pose risks for those with clotting disorders or severe liver disease. In these cases, medical supervision is recommended before supplementation.